Estimate the scale of the system you are going to design...
Define what APIs are expected from the system...
For user
Defining the system data model early on will clarify how data will flow among different components of the system. Also you could draw an ER diagram using the diagramming tool to enhance your design...
Components
Explain how the request flows from end to end in your high level design. Also you could draw a sequence diagram using the diagramming tool to enhance your explanation...
Explain any trade offs you have made and why you made certain tech choices...
Try to discuss as many failure scenarios/bottlenecks as possible.
What are some future improvements you would make? How would you mitigate the failure scenario(s) you described above?