Core functionality
Non-Core functionality
Scaling and Performance
Data Storage
Real-Time Features
Security Considerations
Cache
Monitoring & Alerting
Login/ Authentication
Tweet Service (CRUD)
Feed Service
Notification Service
User Service
Defining the system data model early on will clarify how data will flow among different components of the system. Also you could draw an ER diagram using the diagramming tool to enhance your design...
User
Profile
Tweet
Comments
Media
Notifications
Followers
Read
Create
Explain how the request flows from end to end in your high level design. Also you could draw a sequence diagram using the diagramming tool to enhance your explanation...
Dig deeper into 2-3 components and explain in detail how they work. For example, how well does each component scale? Any relevant algorithm or data structure you like to use for a component? Also you could draw a diagram using the diagramming tool to enhance your design...
Explain any trade offs you have made and why you made certain tech choices...
Try to discuss as many failure scenarios/bottlenecks as possible.
What are some future improvements you would make? How would you mitigate the failure scenario(s) you described above?